Coronary Artery Research Paper

Myocardial-perfusion cardiovascular MRI is noninferior to invasive angiography and fractional flow reserve for guiding coronary revascularization in patients with stable angina and risk factors for coronary artery disease. uses cookies to improve performance by remembering your session ID when you navigate from page to page.

Methods In this SCOT-HEART (Scottish COmputed Tomography of the HEART Trial) post hoc analysis, the presence of adverse plaque (positive remodeling or low attenuation plaque), obstructive disease, and coronary artery calcification within 15 coronary segments was assessed on coronary computed tomography angiography of 1,769 patients who were followed-up for 5 years.Coronary artery disease (CAD) is the most common type of heart disease.It is the leading cause of death in the United States in both men and women.CAD happens when the arteries that supply blood to heart muscle become hardened and narrowed.This is due to the buildup of cholesterol and other material, called plaque, on their inner walls. As it grows, less blood can flow through the arteries.NIH: National Heart, Lung, and Blood Institute Medline Plus links to health information from the National Institutes of Health and other federal government agencies.Medline Plus also links to health information from non-government Web sites.Recent data have suggested that positive remodeling and low attenuation plaque in particular provide the most useful prognostic information (2,5), although it remains unclear whether this is of incremental value to traditional cardiovascular risk factors or coronary plaque burden.In the SCOT-HEART (Scottish COmputed Tomography of the HEART) prospective, multicenter, randomized controlled trial of patients with stable chest pain, the addition of coronary CTA to routine care led to improved diagnostic certainty and patient care that ultimately reduced the rate of coronary heart disease death or nonfatal myocardial infarction (6–8).n = 16 of 1,161 [1.4%]; p Conclusions Adverse coronary plaque characteristics and overall calcified plaque burden confer an increased risk of coronary heart disease death or nonfatal myocardial infarction.(Scottish COmputed Tomography of the HEART Trial [SCOT-HEART]; NCT01149590)The investigation of patients with suspected coronary artery disease has previously focused on functional assessments that attempt to identify the presence of myocardial ischemia as a downstream surrogate marker of proximal coronary artery stenoses.


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