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They protect the cell from external influences, organize the interior in distinct compartments and allow balanced flux of components.
Using their DNA, mitochondria are able to encode for some of the components they require to perform their functions.
- Unlike the smooth ER, rough ER has ribosome attached to its surface.
It is involved in the manufacture of various proteins in the cell.
The origin of most lipids imported into mitochondria is the endoplasmic reticulum, which requires interaction of these two subcellular compartments.
Recently, protein complexes that are involved in membrane contact between endoplasmic reticulum and mitochondria were identified, but their role in lipid transport is still unclear.